Will Smith
as Robert Neville

Alice Braga
as Anna Montez

Charlie Tahan
as Ethan

Dash Mihok
as Alpha Male

Salli Richardson-Whitfield
as Zoe Neville

Willow Smith
as Marley Neville

Emma Thompson
as Dr. Alice Krippin

Darrell Foster
as Mike - Military Escort

Joanna Numata
as Alpha Female

Samuel Glen
as Military Driver - Jay

Pedro Mojica
as Sergeant

Marin Ireland
as Woman Evacuee

Alexander DiPersia
as Male Evacuee

April Grace
as TV Personality

James McCauley
as Male Evacuee

Anthony C. Mazza
as Evacuation Cop

Steve Cirbus
as Military Police

Calista Hill
as Little Girl Evacuee

Gabriella Hill
as Little Girl Evacuee

Madeline Hill
as Little Girl Evacuee

Adhi Sharma
as Military Scanning Tech

Tyree Michael Simpson
as Evacuation Cop #2

Blake Lange
as Coast Guard Ground Crew

Abraham Sparrow
as Male Evacuee #3

Pat Fraley
as President (voice)

Caitlin McHugh
as Special Blond Model

Deborah Collins
as Civilian

Mike Patton
as Creatures (voice)

Katherine Brook
as Infected

Vince Cupone
as Infected

Lynna Davis
as Infected

Anika Ellis
as Infected

John Grady
as Infected

Moses Harris Jr.
as Infected

Kennis Hawkins
as Infected

Marc Inniss
as Infected

Eric Jenkins
as Infected

Reed Kelly
as Infected

Grasan Kingsberry
as Infected

Drew Leary
as Infected

Asa Liebmann
as Infected

Deborah Lohse
as Infected

Jon-Paul Mateo
as Infected

Ian Mclaughlin
as Infected

Luke Miller
as Infected

Courtney Munch
as Infected

Kimberly Shannon Murphy
as Infected

Okwui Okpokwasili
as Infected

Erin Owen
as Infected

Victor Paguia
as Infected

Paradox Pollack
as Infected

Will Rawls
as Infected

William Schultz
as Infected

Hollie K. Seidel
as Infected

Hannah Sim
as Infected

Eric Spear
as Infected

Mark Steger
as Infected

Charlie Sutton
as Infected

David Hamilton Thomson
as Infected

Anthony Vincent
as Infected

Greg Wattkis
as Infected

Raul Torres
as Male Evacuee (uncredited)