Leslie Nielsen
as Frank Drebin

Priscilla Presley
as Jane Spencer

Ricardo Montalban
as Vincent Ludwig

George Kennedy
as Ed Hocken

O.J. Simpson
as Nordberg

Susan Beaubian
as Mrs. Nordberg

Nancy Marchand
as Mayor

Raye Birk
as Pahpshmir

Jeannette Charles
as Queen Elizabeth II

Ed Williams
as Ted Olsen

Tiny Ron
as Al

"Weird Al" Yankovic
as 'Weird Al'

Leslie Maier
as 'Weird Leslie'

Winifred Freedman
as Stephanie

Joe Grifasi
as Foreman

Tony Brafa
as Enrico Pallazzo

Lorali Hart
as Woman On Ledge

Nicholas Worth
as Thug #1

Ronald G. Joseph
as Thug #27

Doris Hess
as Nurse #2

Charlotte Zucker
as Dominique

Larry Pines
as Drug Dealer #1

Tom Dugan
as Drug Dealer #2

Burton Zucker
as Photographer

David Katz
as Arafat

Robert LuJane
as Khadafi

Charles Gherardi
as Khomeini

Prince Hughes
as Idi Amin

David Lloyd Austin
as Gorbachev

Ken Minyard
as Ken & (voice)

Robert Arthur
as Bob (voice)

Greg Breslau
as Man Deleted from Fireworks Scene

Sharon Breslau
as Woman Deleted from Fireworks Scene

Reggie Jackson
as Angel Right Fielder

Michael J. Montes
as Angel Shortstop

Charles Fick
as Angel Catcher

Lawrence Tierney
as Angels Manager

Hank Robinson
as First Base Umpire

Joe West
as Third Base Umpire

Jay Johnstone
as Seattle First Up

Randy Harvey
as Seattle Pitcher

Brett Bartlett
as Seattle Centerfielder

Dennis Packer
as Baseball P.A. Announcer

Dick Vitale
as Baseball Announcer

Dick Enberg
as Baseball Announcer

Jim Palmer
as Baseball Announcer

Mel Allen
as Baseball Announcer

Curt Gowdy
as Baseball Announcer

Tim McCarver
as Baseball Announcer

Joyce Brothers
as Baseball Announcer

Don Woodard
as "There he is!"

Christopher J. Keene
as "Please disperse, Please disperse."

Mary Norman
as "Here, you can use my radio mike."

Susan Breslau
as "Hey, look out!"

Rick Seaman
as "Ya dumb broad!"

Fredric Arnold
as "Hey! What's the meaning of this?"

Ron Tank
as "Mayor, will there be any additional security officers added to the police force during the Queen's visit?"

Mallory Sandler
as "Oh, Dr. Alford, I have Mrs. Kepley's chart if you're ready to go over it."

Edwina Moore
as "Mr. Pallazzo, our head usher will be here in two minutes to take you onto the field."

Jeff Wright
as "Mr. Pallazzo! Would you come with me?"

Jim Smith
as "Sorry, fellas."

Mark Holton
as "It's Enrico Pallazzo!"

Jane Couris
as "You killed him!"

John Houseman
as Driving Instructor (uncredited)

Brinke Stevens
as Brunette Woman in Showers (uncredited)

Jesse Ventura
as Baseball Announcer (uncredited)

Bob Herron
as Dr. Alford (uncredited)

Eddie Hice
as Criminal at Police Station / Baseball Fan (uncredited)

Conrad E. Palmisano
as Hijacked Taurus Driver (uncredited)