Teresa Wright
as Charlie Newton

Joseph Cotten
as Charlie Oakley

Macdonald Carey
as Jack Graham

Henry Travers
as Joseph Newton

Patricia Collinge
as Emma Newton

Hume Cronyn
as Herbie Hawkins

Wallace Ford
as Fred Saunders

Edna May Wonacott
as Ann Newton

Charles Bates
as Roger Newton

Irving Bacon
as Station Master

Clarence Muse
as Pullman Porter

Janet Shaw
as Louise Finch

Estelle Jewell
as Catherine

Virginia Brissac
as Mrs. Phillips (uncredited)

Frances Carson
as Mrs. Potter (uncredited)

Earle S. Dewey
as Mr. Norton (uncredited)

Sarah Edwards
as Doctor's Wife on Train (uncredited)

Edward Fielding
as Doctor on Train (uncredited)

Vaughan Glaser
as Dr. Phillips (uncredited)

Alfred Hitchcock
as Man on Train Playing Cards (uncredited)

Shep Houghton
as Ballroom Dancer (uncredited)

Ruth Lee
as Mrs. MacCurdy (uncredited)

Eily Malyon
as Mrs. Cochran (uncredited)

John McGuire
as Teen at Crosswalk (uncredited)

Shirley Mills
as Shirley (uncredited)

Constance Purdy
as Mrs. Martin (uncredited)

Robert Quarry
as Santa Rosa Teenager (uncredited)

Isabel Randolph
as Margaret Green (uncredited)

Grandon Rhodes
as Rev. MacCurdy (uncredited)

Byron Shores
as Detective (uncredited)

Edwin Stanley
as Mr. Green (uncredited)

Minerva Urecal
as Mrs. Henderson (uncredited)