Keanu Reeves
as Johnny Mnemonic

Dina Meyer
as Jane

Takeshi Kitano
as Takahashi

Ice-T
as J-Bone

Dolph Lundgren
as Street Preacher

Denis Akiyama
as Shinji

Henry Rollins
as Spider

Barbara Sukowa
as Anna Kalmann

Udo Kier
as Ralfi

Tracy Tweed
as Pretty

Falconer Abraham
as Yomamma

Don Francks
as Hooky

Diego Chambers
as Henson

Sherry Miller
as Takahashi's Secretary

Arthur Eng
as Viet

Von Flores
as Viet

Victoria Tengelis
as Pharmakom Receptionist

Warren Sulatycky
as Yakuza Operator

Celina Wu
as Mikiyo

Jamie Elman
as Toad

Simon Sinn
as Man in Hotel Lobby

Caitlin Carmody
as Twin in Hotel Lobby

Erin Carmody
as Twin in Hotel Lobby

Douglas O'Keeffe
as Pharmakom Security Officer

Marlow Vella
as Lotek Kid

Howard Szafer
as Strike

Paul Brogren
as Stump

Arthi Sambasivan
as Nurse

Michael A. Miranda
as Stick

Coyote Shivers
as Buddy

Lynne Adams
as Yakuza with Rocket Launcher

Michael Shearer
as Yakuza Partner

Susan Tsagkaris
as Opera Singer

Chris Comrie
as Beijing Riot Newscaster

Gene Mack
as Laslo

Robin Crosby
as Girl in Hotel Room

Glenn Bang
as Bandleader (uncredited)

Natalie Gray
as Tall Chinese Man (uncredited)