Daniel Radcliffe
as 'Weird Al' Yankovic

Evan Rachel Wood
as Madonna

Rainn Wilson
as Dr. Demento

Toby Huss
as Nick Yankovic

Jack Lancaster
as Jim

Spencer Treat Clark
as Steve

Tommy O'Brien
as Bermuda

Arturo Castro
as Pablo Escobar

Julianne Nicholson
as Mary Yankovic

Diedrich Bader
as Grizzled Narrator (voice)

Lin-Manuel Miranda
as Doctor

Richard Aaron Anderson
as Young Al

Thomas Lennon
as Salesman

David Bloom
as Teenage Al

Keanush Tafreshi
as Kip

Andrew Steven Hernandez
as Robbie

Paloma Esparza Rabinov
as Hipster Teen

Scott Aukerman
as Police Officer

Johnny Pemberton
as Johnny Barf

Jonah Ray
as Jonah Barf

Jeremy Bolm
as Jeremy Barf

Eric Appel
as Captain Buffoon (voice)

'Weird Al' Yankovic
as Tony Scotti

Will Forte
as Ben Scotti

Patton Oswalt
as Heckler

Michael McKean
as Sleazy MC

Dot-Marie Jones
as Mama Bear

Dean Sharpe
as Bartender

Jorma Taccone
as Pee-Wee Herman

Demetri Martin
as Tiny Tim

Paul F. Tompkins
as Gallagher

Akiva Schaffer
as Alice Cooper

Conan O'Brien
as Andy Warhol

Emo Philips
as Salvador Dali

Nina West
as Divine

Jack Black
as Wolfman Jack

David Dastmalchian
as John Deacon

Anthony N.
as Security Guard

Quinta Brunson
as Oprah Winfrey

Julie Chang
as Connie Chung

Josh Groban
as Waiter

Seth Green
as Radio DJ (voice)

Constantine Rousouli
as Cone-Bra Dancer #1

James Brown III
as Cone-Bra Dancer #2

Rocky Abou-Sakher
as Terrorist Diner Patron

Chris Ryan
as Kidnapper

Mike Escamilla
as Guard #1

Chad Guerrero
as Guard #2

Cesar Ramirez
as Mariachi Band Member #1

Omar Estrada
as Mariachi Band Member #2

Cesar Chavira
as Mariachi Band Member #3

Jimmy Walker Jr.
as Floor Manager

Trenyce
as Diana Ross

James Preston Rogers
as Hulk Hogan

William Guirola
as Sicario

Paul Riley Fox
as Elton John (uncredited)

Gordon Tarpley
as David Bowie (uncredited)

Lisa Margaroli
as Elvira, Mistress of the Dark (uncredited)

Erin O'Shea
as Kate Pierson (uncredited)