Steve Carell
as Dodge Petersen

Keira Knightley
as Penelope "Penny" Lockhart

Connie Britton
as Diane

Rob Corddry
as Warren

Adam Brody
as Owen

Derek Luke
as Alan Speck

Martin Sheen
as Frank Petersen

Melanie Lynskey
as Karen Amalfi

Nancy Carell
as Linda Petersen

William Petersen
as Trucker

Gillian Jacobs
as Waitress / Katie

T.J. Miller
as Chipper Host / Darcy

Patton Oswalt
as Roache

Bob Stephenson
as Officer Wally Johnson

Brad Morris
as Radio Announcer (voice)

Mark Moses
as Anchorman

Roger Aaron Brown
as Alfred

Rob Huebel
as Jeremy

Trisha Gorman
as Crying Woman

Tonita Castro
as Elsa

Leslie Murphy
as Amy

Kasey Campbell
as Danny

Vince Grant
as Man #1 / Chip

Amy Schumer
as Woman #1 / Lacey

Marshall Manesh
as Indian Man

Aleister
as Sorry

Rene Gube
as Cell-Mate

Jim O'Heir
as Cop #2

Daniel Maurio
as Toilet Guy

Matthew Alan Brady
as Kissing Couple In Park (uncredited)

Tony Brown
as Gay Party Guest (uncredited)

Lauren Crawford
as Bikini Girl (uncredited)

Laura Mann
as Sarah (uncredited)

Prestin Persson
as Bikini Girl (uncredited)

Lauren K. Solomon
as Kissing Friendsy's Customer (uncredited)

Chris Spinelli
as Cyclist (uncredited)

Hannah Victoria Stock
as Party Girl (uncredited)