Meg Ryan
as Annie Reed

Tom Hanks
as Sam Baldwin

Ross Malinger
as Jonah Baldwin

Bill Pullman
as Walter

Rosie O'Donnell
as Becky

Barbara Garrick
as Victoria

Rob Reiner
as Jay

Gaby Hoffmann
as Jessica

Rita Wilson
as Suzy

Victor Garber
as Greg

Tom Riis Farrell
as Rob

Carey Lowell
as Maggie Baldwin

Le Clanché du Rand
as Barbara Reed

Kevin O'Morrison
as Cliff Reed

David Hyde Pierce
as Dennis Reed

Valerie Wright
as Betsy Reed

Frances Conroy
as Irene Reed

Tom Tammi
as Harold Reed

Calvin Trillin
as Uncle Milton

Caroline Aaron
as Dr. Marcia Fieldstone

Linda Wallem
as Loretta

LaTanya Richardson Jackson
as Harriet

Tom McGowan
as Keith

Steve Mellor
as Wyatt

Marguerite Schertle
as Baltimore Waitress

Dana Ivey
as Claire

Brian McConnachie
as Bob

Matt Smith
as Mailman

Amanda Maher
as Clarise

Victor Morris
as Seattle Maitre D'

Philip Mihalski
as Seattle Waiter

Donald J. Lee Jr.
as Seattle Detective

Mary A. Kelly
as Nervous Woman on Airplane

Diane Sokolow
as Tiffany Saleswoman

Hannah Cox
as Jessica's Mother

Rich Hawkins
as Jessica's Father

Tamara Plank
as Stewardess

Michael Badalucco
as New York Taxi Dispatcher

Jeff Mazzola
as New York Taxi Dispatcher

Philip Levy
as Taxi Driver

Julie Janney
as Cynthia

Tony Zazula
as Maitre D'

John Boylan
as Elevator Man

Robert Livingston
as Elevator Man

Butch Stevenson
as Valet

Sidney Armus
as Information Booth Man

Philip Anagnos
as Car Driver (uncredited)

Jason Bortz
as Baltimore Mail Clerk (uncredited)

Scott Duthie
as Tourist (uncredited)

William Rossman
as Driver (uncredited)

Nick Taylor
as Bartender (uncredited)