Will Smith
as Muhammad Ali / Cassius Clay

Jamie Foxx
as Drew 'Bundini' Brown

Jon Voight
as Howard Cosell

Mario Van Peebles
as Malcolm X

Ron Silver
as Angelo Dundee

Jeffrey Wright
as Howard Bingham

Mykelti Williamson
as Don King

Jada Pinkett Smith
as Sonji Roi

Nona Gaye
as Belinda Ali

Michael Michele
as Veronica Porche

Joe Morton
as Chauncey Eskridge

Paul Rodríguez
as Dr. Ferdie Pacheco

Bruce McGill
as Bradley

Barry Shabaka Henley
as Herbert Muhammad

Giancarlo Esposito
as Cassius Clay, Sr.

Laurence Mason
as Luis Sarria

LeVar Burton
as Martin Luther King, Jr.

Albert Hall
as Elijah Muhammad

David Cubitt
as Robert Lipsyte

Ted Levine
as Joe Smiley

Candy Ann Brown
as Odessa

David Elliott
as Sam Cooke

Shari Watson
as Woman Singer

Malick Bowens
as Joseph Mobutu

Michael Bentt
as Sonny Liston

James Toney
as 'Smokin' Joe Frazier

Alfred Cole
as Ernie Terrell

Charles Shufford
as George Foreman

Rufus Dorsey
as Floyd Paterson

Robert Sale
as Jerry Quarry

Vince Cooke
as Jimmy Ellis

Damien 'Bolo' Wills
as Ken Norton

David Haines
as Rudy Clay / Rahaman Ali

Victoria Dillard
as Betty Shabazz

Brad Greenquist
as Marlin Thomas

Morgana Van Peebles
as Malcolm X's Daughter

Maya Van Peebles
as Malcolm X's Daughter

Maestro Harrell
as Young Cassius Clay

William Utay
as The Doctor

Kim Robillard
as Jimmy Cannon

David Purdham
as Madison Square Garden Announcer

Gailard Sartain
as Gordon Davidson

Wade Williams
as Lieutenant Jerome Claridge

Guy Van Swearingen
as Induction FBI Man

Doug Hale
as Judge Ingraham

LaDonna Tittle
as Bundini's Landlady

Marc Grapey
as Bob Arum

Herb Mitchell
as Boxing Commissioner

Eddie Bo Smith Jr.
as Malcolm's Bodyguard

Bobby Stuart
as Thomas 15X Johnson

Patrick New
as Room Service Guy

Ron O.J. Parson
as Death Newsman

Ellis Williams
as Family Photo Man

Alexandra Bokyun Chun
as Asian Cosmetologist

John Gleeson Connolly
as Assistant Director

Warner Saunders
as Customer

Jack Reiss
as Referee Arthur Mercante

Marty Denkin
as Frazier Fight II Announcer

Tamara Lynch
as Flight Attendant

Chico Benymon
as Hampton House Announcer

Bill Plaschke
as Miami Weigh-In Reporter

Steve Springer
as Miami Weigh-In Reporter

Patrick M. Connolly
as Announcer

Patrick C. Russell
as Referee

Robert Byrd
as Willie Reddick

Cedric Wills
as Jersey Joe Walcott, Referee

Ronald A. DiNicola
as Prosecutor

Moses Hollins
as Man on Train

Daniel E. Gurevitz
as Boxing Commission Reporter

Steven Randazzo
as Reporter

Ray Bokhour
as Reporter

Leonard Termo
as Madison Square Garden Reporter

Johnny Ortiz
as Madison Square Garden Reporter

Mark Salem
as New York Reporter

Sheldon Fogel
as New York Reporter

Jim Gray
as New York Reporter

Melvin Thomas
as Harlem Neighbor

Natalie Carter
as Harlem Neighbor

Reginald Footman
as Harlem Neighbor

Poe Poe
as Harlem Reporter

Mel Dick
as Louisville Sponsoring Group

Kim Taylor-Coleman
as Lana Shabazz

Christian Stolte
as Miami Cop

Vic Manni
as Dressing Room Weigh-In Guy

Will Gill Jr.
as Dick Sadler

Sylvaine Strike
as ORTF Interviewer

Denis Luposo
as Kinshasa Reporter

Sharon Wilkinson
as Rose Jennings

Carol Hatchett
as Pointer Sister

Judith Mwale
as Pointer Sister

Keabetswe Motsilanyane
as Pointer Sister

Richard Katanga
as Mobutu Aide / Military Aide

Thomas Kariuki Matheri
as Lieutenant Nsakala

Larry Hazzard Sr.
as Zack Clayton

Derrick Brown
as Larry Holmes

Rommel Hyacinth
as The Pilot

Graham Hopkins
as London Banker

Daniel Janks
as CIA Man

Bradford E. Lang
as Black Pilot

Michael Dorn
as Black Pilot

Dan Robbertse
as Reporter in Zaire

Graham Clarke
as Reporter in Zaire

Dimitri Cassar
as Reporter in Zaire

Frank Notaro
as Reporter in Zaire

Mark Mulder
as Reporter in Zaire

David W. Hess
as Reporter in Zaire

Henrikennyo Mukenyi
as Bula

Nathaniel Malekane
as Archie Moore

Millard Arnold
as Doc Broadus

Edda Collier
as Blonde French Reporter

Yi Lu Wei
as Chinese Delegate

Lee Cummings
as Hunter Thompson

Zaa Nkweta
as Foreman Fight Announcer

Themba Gasa
as Idi Amin

Andrew P. Jones
as Don King's Aide

Marc Kulazite Mboli
as Additional Aide to Mobutu

Cimanga Kalambay
as Additional Aide to Mobutu

Jean Bikoi
as Additional Aide to Mobutu

James Gilbert
as Sparring Partner in Africa