Leonardo DiCaprio
as Dr. Randall Mindy

Jennifer Lawrence
as Kate Dibiasky

Meryl Streep
as President Orlean

Cate Blanchett
as Brie Evantee

Rob Morgan
as Dr. Teddy Oglethorpe

Jonah Hill
as Jason Orlean

Mark Rylance
as Peter Isherwell

Tyler Perry
as Jack Bremmer

Timothée Chalamet
as Yule

Ron Perlman
as Benedict Drask

Ariana Grande
as Riley Bina

Kid Cudi
as DJ Chello

Himesh Patel
as Phillip

Melanie Lynskey
as June Mindy

Michael Chiklis
as Dan Pawketty

Tomer Sisley
as Adul Grelio

Paul Guilfoyle
as General Themes

Robert Joy
as Congressman Tenant

Jack Alberts
as Oliver

Ting
as Win

Lance A. Williams
as Daniel

Shimali de Silva
as Nisha

Hettienne Park
as Dr. Calder

Rafael Silva
as Nasa Scientist

Lonnie Farmer
as Old Aide #1

Homa Sarabi-Daunis
as White House Office Worker

Barbara Douglass
as Office Worker

Rena Maliszewski
as Anchor Reporting On Colon

Erik Parillo
as Sherriff Conlon

Robert Hurst Radochia
as Evan Mindy

Conor Sweeney
as Marshall Mindy

Ross Partridge
as Keith Ollens

Richard Donelly
as Old Aide #2

Liev Schreiber
as Bash Narrator (voice)

Samsara Yett
as Isherwell Child Aide

Meara Mahoney Gross
as Isherwell Child Aide

Jaden Onwuakor
as Isherwell Child Aide

Staci Roberts
as Linda Dicalio

Wendy Bellevue
as Isherwell Child Handler

Mishka Yarovoy
as Executive

Chris Everett
as Chief Editor Paula Woods

Annette Miller
as Mrs. Tanken

Stephen Thorne
as Benjamin

Aimee Doherty
as Passerby

Natalie Rebenkoff
as Talent PA

Gary Tanguay
as News Anchor #2

Georgia Lyman
as Groomer Thalia

Patricia DeHaney
as Hair Person

Ben Sidell
as Stage Manager

Therese Plaehn
as Autopsy Editor In Charge

Omar Ghonim
as Damian

Jody O'Neil
as Stage Manager #2

Meghan Leathers
as Media Quant

Ashleigh Banfield
as Dalia Hensfield

Sarah Silverman
as Sarah Benterman

Richard Snee
as Senator Lerner

Darryl Wooten
as FBI Agent

Danielle Waxman
as College Girl

Jeffrey Smith
as Blind Man FBI Agent

Jon Glaser
as Meow Man

Dorothy Dwyer
as Old Tough Lady

Odis Spencer
as Chief Justice

Sarah Nolen
as Sammy Puppeteer

Alvin Keith
as Harrison Telms

Alaina Pinto
as American Reporter

Lizzie Short
as French Reporter

Juri Love
as Japanese Reporter

Sujoy De
as Hindi Reporter

Brahms Guignard
as Haitian Reporter

Sergei Bushmanov
as Russian Reporter

Lewis D. Wheeler
as Mission Coordinator

Steve Gagliastro
as Onlooker

David J. Curtis
as Guy

Kevin Craig West
as Secretary of State

Alison Weller
as Secretary of Education

Rob Lévesque
as Secretary of Interior

Sam Zephir
as Captain

Dee Nelson
as Dr. Lisa Inez

Beau Allen
as Dr. Talcamont

Rebecca Gibel
as Waitress

Brian Faherty
as Guy from the Bar

Celeste Oliva
as Nearby Diner

Amanda Cass
as Rioting Patron

Roman Mitichyan
as Rioting Patron

Paul Marini
as Rioting Patron

Alex Huynh
as Rioting Patron

Michael Jibrin
as Federal Agent

Bill Mootos
as Federal Attorney

Patti Tippo
as French President

Allyn Burrows
as Mr. Dibiasky

Tori Davis Lawlor
as Mrs. Dibiasky

Joy Lang
as Housewife

June Holmes
as Girl in Commercial

Graham Holmes
as Boy in Commercial

Jacob Sanditen
as Yule's Friend

Anthony Marrese
as Other Friend

Caroline Bergwall
as Teen Girl Friend

Anania Williams
as Short Guy Friend

Nate Richman
as Stocky FBI Agent

Wes Johnson
as Don't Look Up'er

John Bucy
as Don't Look Up'er

Patrick Gover
as Don't Look Up'er

Conrad Perry
as Don't Look Up'er

Matt Rouillard
as Don't Look Up'er

Christopher Deschenes
as Don't Look Up'er

Patrick Michael Strange
as Just Look Up'er

J.P. Aaron
as Just Look Up'er

Daniela August
as Just Look Up'er

Nicholai Senat
as Puppet Show Kid

Alexandra Zilch
as Puppet Show Kid

Jonathan Kobs
as Truthslinger303

Bianca de la Garza
as Entertainment Journalist

Caitlin Ishibashi
as DJ at Concert

Claire Davis
as Bass Player

Elder Isaiah Perez
as Organ Player

Coran Spardakis Henley
as Drummer

Lance Norris
as Loyal Supporter

Ralph M. Studley
as Kid Rock Body Double

Frank Ridley
as Flight Director

Andrew Haserlat
as Mission Tech

Jayne McLendon
as Command Tech

Ishaan Khatter
as Raghav Manavalan

Khaldoun Rajeh
as Egyptian Family

Sheren Rajeh
as Egyptian Family

Khaled Rajeh
as Egyptian Family

Kareem Rajeh
as Egyptian Family

Ahmad Rajeh
as Egyptian Family

Adila Rajeh
as Egyptian Family

J.T. Turner
as Old Billionaire

Ed Peed
as Lobbyist

Zach Holmes
as #LaunchChallenge MeTuber (uncredited)

Chris Evans
as Devin Peters (uncredited)

Marissa Carpio
as Reporter with Big Hair (uncredited)