Ellen Burstyn
as Sara Goldfarb

Jared Leto
as Harry Goldfarb

Jennifer Connelly
as Marion Silver

Marlon Wayans
as Tyrone C. Love

Christopher McDonald
as Tappy Tibbons

Louise Lasser
as Ada

Marcia Jean Kurtz
as Rae

Janet Sarno
as Mrs. Pearlman

Suzanne Shepherd
as Mrs. Scarlini

Joanne Gordon
as Mrs. Ovadia

Charlotte Aronofsky
as Mrs. Miles

Mark Margolis
as Mr. Rabinowitz

Michael Kaycheck
as Donut Cop

Jack O'Connell
as Corn Dog Stand Boss

Chas Mastin
as Lyle Russel

Ajay Naidu
as Mailman

Sean Gullette
as Arnold the Shrink

Samia Shoaib
as Nurse Mall

Peter Maloney
as Dr. Pill

Abraham Abraham
as King Neptune

Aliya Campbell
as Alice

Te'ron A. O'Neal
as Young Tyrone

Denise Dowse
as Tyrone's Mother

Bryan Chattoo
as Brody

Eddie De Harp
as Brody's Henchman Victor

Scott Franklin
as Jailer (voice)

Peter Cheyenne
as Sal the Geep

Brian Costello
as First AD

Abraham Aronofsky
as Newspaper Man on Train

James Chinlund
as Space Oddity

Olga Merediz
as Malin & Block Secretary

Allison Furman
as Malin & Block Office Woman

Robert Dylan Cohen
as Paramedic Greenhill

Ben Shenkman
as Dr. Spencer

Keith David
as Big Tim

Dylan Baker
as Southern Doctor

Shaun O'Hagan
as Ward Attendant Seto

Leland Gantt
as Ward Attendant Penn

Bill Buell
as Court Doctor

Jimmie Ray Weeks
as Prison Guard

Gregg Bello
as E.R. Doctor

Henry Stram
as ECT Technician

Heather Litteer
as Big Tim Party Girl

Jenny Decker
as Big Tim Party Girl

Ami Goodheart
as Big Tim Party Girl

Nina Zavarin
as Big Tim Party Girl

Stanley B. Herman
as Uncle Hank

Scott Bader
as Party Animal

Jim Centofanti
as Party Animal

Scott Chait
as Party Animal

Daniel Clarin
as Party Animal

Ben Cohen
as Party Animal

Eric Cohen
as Party Animal

Brett Feinstein
as Party Animal

Ricky Fier
as Party Animal

John Getz
as Party Animal

Andrew Kessler
as Party Animal

Ross Lombardo
as Party Animal

Carter Mansbach
as Party Animal

Scott Miller
as Party Animal

Todd Miller
as Party Animal

Joshua Pollack
as Party Animal

Craig Rallo
as Party Animal

Geordan Reisner
as Party Animal

Keith Scandore
as Party Animal

David Seltzer
as Party Animal

Chris Varvaro
as Party Animal

Ricardo Viñas
as Party Animal

Chad Weiner
as Party Animal

Jesse Weissberger
as Party Animal

Greg Weissman
as Party Animal

Hubert Selby Jr.
as Laughing Guard

Lianna Pai
as Angelic Nurse

Darren Aronofsky
as Visitor (uncredited)