Cailey Fleming
as Bea

Ryan Reynolds
as Cal

John Krasinski
as Dad / Marshmallow (voice)

Fiona Shaw
as Grandmother

Steve Carell
as Blue (voice)

Phoebe Waller-Bridge
as Blossom (voice)

Louis Gossett Jr.
as Lewis (voice)

Alan Kim
as Benjamin

Liza Colón-Zayas
as Janet

Bobby Moynihan
as Jeremy

Catharine Daddario
as Bea’s Mom

Audrey Hoffman
as Bea (Ages 3 & 5)

Laquet Sharnell Pringle
as Receptionist

Ed Herbstman
as Deli Guy

Barbara Andres
as Woman Upstairs

Alexander Rivero
as Custodian

Shauna Pinkett
as Hospital Receptionist

Sa'Raya Paris Johnson
as 7 Year-Old Girl

Marta Siteiya Moipei
as Coffee Shop Barista

David Weissmann
as Young Jeremy

Awkwafina
as Bubble (voice)

Emily Blunt
as Unicorn (voice)

George Clooney
as Spaceman (voice)

Bradley Cooper
as Ice (voice)

Matt Damon
as Flower (voice)

Bill Hader
as Banana (voice)

Richard Jenkins
as Art Teacher (voice)

Keegan-Michael Key
as Slime (voice)

Blake Lively
as Octopuss (voice)

Sebastian Maniscalco
as Magician Mouse (voice)

Christopher Meloni
as Cosmo (voice)

Matthew Rhys
as Ghost (voice)

Sam Rockwell
as Guardian Dog (voice)

Maya Rudolph
as Alligator (voice)

Amy Schumer
as Gummy Bear (voice)

Allyson Seeger
as Viola (voice)

Jon Stewart
as Robot (voice)

Craig 'Radioman' Castaldo
as Radio Man (uncredited)