Yahya Abdul-Mateen II
as Anthony McCoy

Teyonah Parris
as Brianna Cartwright

Colman Domingo
as William Burke

Nathan Stewart-Jarrett
as Troy Cartwright

Kyle Kaminsky
as Grady Smith

Vanessa Williams
as Anne-Marie McCoy

Brian King
as Clive Privler

Miriam Moss
as Jerrika

Rebecca Spence
as Finley Stephens

Carl Clemons-Hopkins
as Jameson

Christiana Clark
as Danielle Harrington

Michael Hargrove
as Candyman / Sherman Fields

Rodney L Jones III
as Billy

Ireon Roach
as Trina

Breanna Lind
as Annika

Heidi Grace Engerman
as Haley Gulick

Sarah Lo
as Samantha

Ro White
as Boof

Mark Montgomery
as Detective Lipez

Torrey Hanson
as Jack Hyde

Cassie Kramer
as Librarian

Sarah Wisterman
as Celine

Cedric Mays
as Gil Cartwright

Alec Silver
as Restaurant server

Hannah Love Jones
as Young Brianna

J. Nicole Brooks
as Dr. Collins

Pamela Jones
as Reporter Devlin Sharpe

Genesis Denise Hale
as Sabrina

Katherine Purdie
as Haley's Mom

Tien Tran
as Jane Ji

Mike Geraghty
as Police Officer Jones

Aaron Crippen
as Police Officer Smith

Dan Fierro
as Police Officer Rooney

Nadia Simms
as Ringleader

Nancy Pender
as TV News Anchor

Johnny Westmoreland
as Samuel Evans

Guy Spencer
as John Crawley

Daejon Staeker
as The Kid

Tony Todd
as Candyman / Daniel Robitaille

Virginia Madsen
as Helen Lyle (voice)

Ben Marten
as Officer Cooke (uncredited)