Matthew Rhys
as Lloyd Vogel

Tom Hanks
as Fred Rogers

Chris Cooper
as Jerry Vogel

Susan Kelechi Watson
as Andrea Vogel

Maryann Plunkett
as Joanne Rogers

Enrico Colantoni
as Bill Isler

Wendy Makkena
as Dorothy Vogel

Tammy Blanchard
as Lorraine Vogel

Noah Harpster
as Todd

Carmen Cusack
as Margy Whitmer

Kelley Davis
as First AD

Christine Lahti
as Ellen

Maddie Corman
as Betty Aberlin

Daniel Krell
as Mr. McFeely

Jon L Peacock
as Sound Technician

Gretchen Koerner
as Doctor

Gavin Borders
as Young Boy

Mark August
as Young Boy's Dad

Tressa Glover
as Young Boy's Mom

Jessica Hecht
as Lila Vogel

Di Zhu
as Waitress

Diane Monroe
as Uptown String Quartet

Maxine Roach
as Uptown String Quartet

Lesa Terry
as Uptown String Quartet

Tahirah Whittington
as Uptown String Quartet

Nigel Swinson
as Subway Singer

Kayla Fan
as Subway Singer

Alexander Ment
as Subway Singer

Madeline Ment
as Subway Singer

Olivia Irene Ruiz
as Subway Singer

Kiesse Yengo-Passy
as Subway Singer

Marcel Kottmann
as Subway Singer

John Castagliola
as Subway Singer

Preston Lopez
as Subway Singer

Reginald Bannerman
as Subway Singer

Spencer Lott
as Puppeteer

Haley Jenkins
as Puppeteer

Marc Petrosino
as Puppeteer

Kathleen Kim
as Puppeteer

Kathleen Antonia
as Phone Operator (uncredited)

Saira Awan
as Nurse Miscellaneous Crew (uncredited)

Krizia Bajos
as Argentinian Girl (uncredited)

Tom Bonello
as WQED Grip and Electric (uncredited)

Gregory Bromfield
as Awards Banquet Waiter (uncredited)

Francesca Calo
as Train Passenger (uncredited)

Kitty Crystal
as Subway Punk (uncredited)

Amy Lyn Elliott
as WQED Makeup Artist (uncredited)

Joe Fishel
as Journalist (uncredited)

Nate Heller
as Wedding Band Lead Guitarist (uncredited)

Bill Isler
as Restaurant Patron (uncredited)

Kevin L. Johnson
as Darin Scharf (uncredited)

Rosie Koster
as Esquire Employee (uncredited)

Michael Masini
as Richie (uncredited)

Kirsten McCain
as Gala Attendee (uncredited)

Patrick McDade
as Rick (uncredited)

David Newell
as Restaurant Patron (uncredited)

Trevor Stevie Ray Ontiveros
as New Yorker (uncredited)

Keith Otto
as Gala Attendee (uncredited)

Khary Payton
as Arthur Mendez - Telegraph Clerk (uncredited)

Alex Pérez
as Parent (uncredited)

Katrina E. Perkins
as Mr. Rogers Superfan (uncredited)

Jivan Xander Ramesh
as Mr. Rogers' Fan (uncredited)

Scott Rapp
as Bartender (uncredited)

Fred Rogers
as Self (archive footage) (uncredited)

Joanne Rogers
as Restaurant Patron (uncredited)

Edlyn Sabrina
as Gala Guest (uncredited)

Erika Shrout
as Mother (uncredited)

Laura Faye Smith
as Julia Henderson - Fred's Secretary (uncredited)

Rebecca Watson
as Diana (uncredited)

Stephen West-Rogers
as Peter (uncredited)

Ted Williams
as WQED Electrician (uncredited)

Jackson Nunn
as Grip (uncredited)