John C. Reilly
as Eli Sisters

Joaquin Phoenix
as Charlie Sisters

Jake Gyllenhaal
as John Morris

Riz Ahmed
as Hermann Kermit Warm

Rebecca Root
as Mayfield

Allison Tolman
as Girl Mayfield Saloon

Rutger Hauer
as The Commodore

Carol Kane
as Mrs Sisters

Patrice Cossonneau
as Blount

Zac Abbott
as Blount Guy Dying

David Gasman
as Relay Owner

Philip Rosch
as Storekeeper Pioneer Town 2

Creed Bratton
as Quarrel Saloon Guy Town 02

Lenuta Bala
as Woman with the Bortsch

Jochen Hägele
as Horse Dealer Town 03

Eric Colvin
as Horse Dealer Relay 02

Ian Reddington
as The Father

Aldo Maland
as Young Eli

Theo Exarchopoulos
as Young Charlie

Sean Duggan
as Jacksonville House Keeper

Raymond Waring
as Mayfield Bartender

Jóhannes Haukur Jóhannesson
as Head Trapper

Gerard Cooke
as Storekeeper Mayfield

Frédéric Siuen
as Pacific Chinese Dad Prospector

Trevor Allan Davies
as Golden Pearl Valet

Aidan O'Hare
as Horse Dealer American River

Andrew Litvack
as Prospector

Nick Cornwall
as Man Encampment Attacker 1

Duncan Lacroix
as Man Encampment Attacker 2

Jean-Marc Bellu
as Man Encampment Attacker 3

Diego Llano
as American River Indian

Hugo Dillon
as Dr Crane

Lexie Benbow-Hart
as Dr Crane’s Daughter

Richard Brake
as Rex

Kelda Holmes
as Poor Woman Commodore