Ed Helms
as Rusty Griswold

Christina Applegate
as Debbie Griswold

Skyler Gisondo
as James Griswold

Steele Stebbins
as Kevin Griswold

Chris Hemsworth
as Stone Crandall

Leslie Mann
as Audrey Griswold

Chevy Chase
as Clark Griswold

Beverly D'Angelo
as Ellen Griswold

Charlie Day
as Chad

Catherine Missal
as Adena

Ron Livingston
as Ethan

Norman Reedus
as Trucker

Keegan-Michael Key
as Jack Peterson

Regina Hall
as Nancy Peterson

Emyri Crutchfield
as Sheila Peterson

Alkoya Brunson
as Gary Peterson

Nick Kroll
as Colorado Cop

Tim Heidecker
as Utah Cop

Kaitlin Olson
as Arizona Cop

Michael Peña
as New Mexico Cop

Hannah Jeter
as Ferrari Girl

David Clennon
as Harry Co-Pilot

Colin Hanks
as Jake

Kirstin Ford
as Mom on Plane

Ethan Maher
as Boy on Plane

Elizabeth Gillies
as Heather

Cristina Squyres
as Brooke

Nadine Avola
as Chelsea

Ryan Cartwright
as Terry

Valerie Payton
as Shuttle Driver

O'Clair Alexander
as Husky Lady at Monument

Miles Doleac
as Man on the Monument

Holly Gardner
as Women at Monument

R.F. Daley
as Furious Husband

Elizabeth Fendrick
as Furious Wife

Michael H. Cole
as Male Guest

Brooke Jaye Taylor
as Female Guest

Matthew Cornwell
as Male Guest #2

Mitchell Warren
as Wally World Kid #2

John Francis Daley
as Ride Operator

Brandon Michael Hale
as Gas Station Clerk (uncredited)

Libby Blake
as Boobs (uncredited)

Rick Ericson
as Hawaiian (uncredited)

Omar Lagudali
as Reporter (uncredited)

Cameron McIntyre
as Young James (age 7 / 9) (uncredited)

Jonathan Goldstein
as Hot Tub Guy (uncredited)

John C. McGinley
as Motorbike Cop