Nicolas Cage
as Charlie Kaufman / Donald Kaufman

Meryl Streep
as Susan Orlean

Chris Cooper
as John Laroche

Tilda Swinton
as Valerie Thomas

Jay Tavare
as Matthew Osceola

Litefoot
as Russell

Roger Willie
as Randy

Jim Beaver
as Ranger Tony

Cara Seymour
as Amelia Kavan

Doug Jones
as Augustus Margary

Gary Farmer
as Buster Baxley

Peter Jason
as Defense Attorney

Gregory Itzin
as Prosecutor

Curtis Hanson
as Orlean's Husband

Agnes NaDene Baddoo
as Orlean Dinner Guest

Paul Fortune
as Orlean Dinner Guest

Paul Jasmin
as Orlean Dinner Guest

Lisa Love
as Orlean Dinner Guest

Wendy Mogel
as Orlean Dinner Guest

David O. Russell
as Orlean Dinner Guest

Judy Greer
as Alice the Waitress

Maggie Gyllenhaal
as Caroline Cunningham

Bob Stephenson
as David

Bob Yerkes
as Charles Darwin

Lynn Court
as Laroche’s Dad

Roger E. Fanter
as Laroche’s Uncle

Sandra Lee Gimpel
as Laroche’s Mom

Caron Colvett
as Laroche’s Wife

Larry Krask
as EMT

Ron Livingston
as Marty Bowen

Brian Cox
as Robert McKee

John Etter
as McKee Lecture Attendee

Ray Berrios
as Police Officer

Nancy Lenehan
as Kaufman’s Mother

John Cusack
as John Cusack (uncredited)

Catherine Keener
as Catherine Keener (uncredited)

John Malkovich
as John Malkovich (uncredited)

Curt Clendenin
as Restaurant Customer (uncredited)

Donald Dowd
as Cafe Customer (uncredited)