Jodie Foster
as Clarice Starling

Anthony Hopkins
as Dr. Hannibal Lecter

Scott Glenn
as Jack Crawford

Ted Levine
as Jame Gumb

Anthony Heald
as Dr. Frederick Chilton

Brooke Smith
as Catherine Martin

Diane Baker
as Senator Ruth Martin

Kasi Lemmons
as Ardelia Mapp

Frankie Faison
as Barney

Tracey Walter
as Lamar

Charles Napier
as Lt. Boyle

Danny Darst
as Sgt. Tate

Alex Coleman
as Sgt. Pembry

Dan Butler
as Roden

Paul Lazar
as Pilcher

Ron Vawter
as Paul Krendler

Roger Corman
as FBI Director Hayden Burke

Lawrence A. Bonney
as FBI Instructor

Lawrence T. Wrentz
as Agent Burroughs

Don Brockett
as Friendly Psychopath

Frank Seals Jr.
as Brooding Psychopath

Stuart Rudin
as Miggs

Maria Skorobogatov
as Young Clarice

Jeffrie Lane
as Clarice's Father

Leib Lensky
as Mr. Lang

George 'Red' Schwartz
as Mr. Lang's Driver

Jim Roche
as TV Evangelist

James B. Howard
as Boxing Instructor

Bill Miller
as Mr. Brigham

Chuck Aber
as Agent Terry

Gene Borkan
as Oscar

Pat McNamara
as Sheriff Perkins

Kenneth Utt
as Dr. Akin

Adelle Lutz
as TV Anchor Woman

Obba Babatundé
as TV Anchor Man

George Michael
as TV Sportscaster

Jim Dratfield
as Sen. Martin's Aide

D. Stanton Miranda
as 1st Reporter

Rebecca Saxon
as 2nd Reporter

Cynthia Ettinger
as Officer Jacobs

Brent Hinkley
as Officer Murray

Steve Wyatt
as Airport Flirt

David Early
as Spooked Memphis Cop

Andre B. Blake
as Tall Memphis Cop

Bill Dalzell
as Distraught Memphis Cop

Chris Isaak
as SWAT Commander

Daniel von Bargen
as SWAT Communicator

Tommy Lafitte
as SWAT Shooter

Josh Broder
as EMS Attendant

Buzz Kilman
as EMS Driver

Harry Northup
as Mr. Bimmel

Lauren Roselli
as Stacy Hubka

Lamont Arnold
as Flower Delivery Man

John Hall
as State Trooper (uncredited)

Ted Monte
as FBI Agent (uncredited)

George A. Romero
as FBI Agent in Memphis (uncredited)

John W. Iwanonkiw
as Orderly (uncredited)

Robert W. Castle
as Priest on Chilton's Plane (uncredited)

Chris McGinn
as Autopsy Victim (uncredited)

Gary Goetzman
as Guido Paonessa (uncredited)

Darla
as Precious