Ben Foster
as Lance Armstrong

Chris O'Dowd
as David Walsh

Guillaume Canet
as Dr. Ferrari

Jesse Plemons
as Floyd Landis

Lee Pace
as Bill Stapleton

Denis Ménochet
as Johan Bruyneel

Edward Hogg
as Frankie Andreu

Dustin Hoffman
as Bob Hamman

Elaine Cassidy
as Betsy Andreu

Laura Donnelly
as Emma O'Reilly

Peter Wight
as Sunday Times Editor

Nathan Wiley
as Charles Pelkey

Chris Larkin
as John Wilcockson

Mark Little
as Rupert Guinness

Michael G. Wilson
as Lance's Doctor

Sid Phoenix
as Tony

Josh O'Connor
as Rich

Sam Hoare
as Stephen Swart

James Harkness
as Wayne

Saskia Reeves
as Conference Director

Chloe Hayward
as Kristin

Adam LeFevre
as Jeffrey Tillotson

Brent Langdon
as Richard Faulkner

J.D. Evermore
as Tailwind Executive

Nicolas Robin
as Christophe Bassons

Julien Vialon
as John Lelangue

Chiké Okonkwo
as Young Hospital Doctor

Daniel Stewart
as Sunday Times Lawyer

Yves Aubert
as Race Official

Paul Kelleher
as Floyd Landis' Father

Philippe Smolikowski
as Jean-Michel Rouet

Lucien Guignard
as Alberto Contador

John Schwab
as Travis Tygart

David Bertrand
as U.C.I. Official

Christy Meyer
as U.S. Sports Journalist