Sandra Bullock
as Scarlet Overkill (voice)

Jon Hamm
as Herb Overkill (voice)

Michael Keaton
as Walter Nelson (voice)

Allison Janney
as Madge Nelson (voice)

Steve Coogan
as Professor Flux / Tower Guard (voice)

Jennifer Saunders
as Reine Elizabeth II (voice)

Geoffrey Rush
as Narrator (voice)

Steve Carell
as Gru (voice)

Pierre Coffin
as Kevin / Stuart / Bob / The Minions (voice)

Katy Mixon
as Tina (voice)

Michael Beattie
as VNC Announcer / Walter Jr. (voice)

Hiroyuki Sanada
as Sumo (voice)

Dave Rosenbaum
as Fabrice (voice)

Alex Dowding
as Royal Advisor (voice)

Paul Thornley
as News Reporter (voice)

Kyle Balda
as Additional Voices (voice)

Ava Acres
as Additional Voices (voice)

Sherry Lynn
as Additional Voices (voice)

Mickie McGowan
as Additional Voices (voice)

Carlos Alazraqui
as Additional Voices (voice)

Lori Alan
as Additional Voices (voice)

Daniel Barker
as Additional Voices (voice)

Bob Bergen
as Additional Voices (voice)

Melanie Bond
as Additional Voices (voice)

Jim Cummings
as Additional Voices (voice)

John Cygan
as Additional Voices (voice)

Brian T. Delaney
as Additional Voices (voice)

Bill Farmer
as Additional Voices (voice)

Keith Ferguson
as Additional Voices (voice)

Jess Harnell
as Additional Voices (voice)

Eve Karpf
as Additional Voices (voice)

John Kassir
as Additional Voices (voice)

Lewis Macleod
as Additional Voices (voice)

Danny Mann
as Additional Voices (voice)

Mona Marshall
as Additional Voices (voice)

Gary Martin
as Additional Voices (voice)

Laraine Newman
as Additional Voices (voice)

Andy Nyman
as Additional Voices (voice)

Alexander Polinsky
as Additional Voices (voice)

Jan Rabson
as Additional Voices (voice)

Christopher Ragland
as Additional Voices (voice)

Mindy Sterling
as Additional Voices (voice)

Tara Strong
as Additional Voices (voice)

Jim Ward
as Additional Voices (voice)

Colette Whitaker
as Additional Voices (voice)

James Daniel Wilson
as Additional Voices (voice)