Adam Sandler
as George Simmons

Seth Rogen
as Ira Wright

Leslie Mann
as Laura

Eric Bana
as Clarke

Jonah Hill
as Leo Koenig

Jason Schwartzman
as Mark Taylor Jackson

Aubrey Plaza
as Daisy Danby

RZA
as Chuck

Aziz Ansari
as Randy

Maude Apatow
as Mable

Iris Apatow
as Ingrid

Torsten Voges
as Dr. Lars

Allan Wasserman
as Dr. Stevens

Rod Man
as Rod Man

Wayne Federman
as Comedy & Magic Manager

Mike O'Connell
as MySpace Escort

James Taylor
as James Taylor

Nicole Parker
as Dawn

Nydia McFadden
as Mandy

Andy Dick
as Andy Dick

Charles Fleischer
as Charles Fleischer

Nicol Paone
as George's Sister

George Coe
as George's Dad

Budd Friedman
as Budd Friedman

Monty Hoffman
as Monty Hoffman

Carol Leifer
as Carol Leifer

Paul Reiser
as Paul Reiser

Mark Schiff
as Mark Schiff

George Wallace
as George Wallace

Norm Macdonald
as Norm Macdonald

Dave Attell
as Dave Attell

Sarah Silverman
as Sarah Silverman

Bryan Batt
as George's Agent

Maggie Siff
as Rachel

Eminem
as Eminem

Ray Romano
as Ray Romano

Jon Brion
as Jon Brion

Sebastian Steinberg
as Sebastian Steinberg

James Gadson
as James Gadson

Arshad Aslam
as Yo Teach Cast Member

Bo Burnham
as Yo Teach Cast Member

Miki Ishikawa
as Yo Teach Cast Member

Kenny Copeland Jr.
as Yo Teach Cast Member

Calvin Sykes
as Yo Teach Cast Member

Ca'Shawn Sims
as Yo Teach Cast Member

Mandi Kreisher
as Yo Teach Cast Member

Phillip Andre Botello
as Yo Teach Cast Member

Carla Gallo
as Miss Pruitt on Yo Teach

Ernest Lee Thomas
as Yo Teach Principal

Tonita Castro
as Bonita

Carlos Andrade
as Gardener

Steve Bannos
as Deli Manager

Justin Long
as Re-Do Guy

Lucas Astrom
as College Guy with Camera

Tyler Spindel
as College Guy with Camera

Deamor Yi
as 8-Year-Old Girl Fan

Elaine Kao
as Mom with Camera

King Kedar
as Family with Camera

Andre Butler Jr.
as Family with Camera

Tanya Acker
as Family with Camera

Jarrett Grode
as Magician

Qiana Chase
as Chuck's Wife

Tom Anderson
as Tom Anderson

John Hartmann
as Private Jet Pilot

Dave Rath
as San Francisco Theatre Manager

Dan Harmon
as Paparazzi at Medical Center

Brandon Cournoyer
as Paparazzi at Medical Center

Kyle Kinane
as Paparazzi at Medical Center

Mark Cohen
as Emcee at Improv

Denise Meyerson
as Deli Customer

Joanie Marx
as Deli Customer

Adam J. Bernstein
as Hot Dog-Eating Champion's Son

Da'Vone McDonald
as Hot Dog-Eating Co-Star

Orny Adams
as Orny Adams

Al Lubel
as Al Lubel

Jerry Minor
as Jerry Minor

Eleanor Zee
as George's Mom

Ben Meyerson
as George's Brother-In-Law

Sammy Jack
as George's Young Nephew

Kim Taylor
as Kim Taylor

Andrea Zonn
as Andrea Zonn

Kate Markowitz
as Kate Markowitz

Arnold McCuller
as Arnold McCuller

Larry Goldings
as Larry Goldings

Luis Conte
as Luis Conte

Russ Kunkel
as Russ Kunkel

Brad Grunberg
as Comedy & Magic Club Audience

Brian Lally
as Comedy & Magic Club Audience

Jimmy Johnson
as Jimmy Johnson

Janeane Garofalo
as Friend in video (archive footage) (uncredited)

Ben Stiller
as Friend in video (archive footage) (uncredited)

Judd Apatow
as Friend in video (voice) (archive footage) (uncredited)