Audrey Tautou
as Amélie Poulain

Mathieu Kassovitz
as Nino Quincampoix

Rufus
as Raphaël Poulain

Lorella Cravotta
as Amandine Poulain

Serge Merlin
as Raymond Dufayel

Jamel Debbouze
as Lucien

Clotilde Mollet
as Gina

Claire Maurier
as Suzanne

Isabelle Nanty
as Georgette

Dominique Pinon
as Joseph

Artus de Penguern
as Hipolito

Yolande Moreau
as Madeleine Wallace

Urbain Cancelier
as Collignon

Maurice Bénichou
as Dominique Bretodeau

Michel Robin
as Mr. Collignon

Andrée Damant
as Mrs. Collignon

Claude Perron
as Eva

Armelle
as Philomène

Ticky Holgado
as Man in Photo

André Dussollier
as Narrator (voice)

Eugène Berthier
as Eugène Koler

Charles-Roger Bour
as Man with Pissoir

Kevin Dias
as Young Dominique

Flora Guiet
as Young Amélie

Amaury Babault
as Young Nino

Marion Pressburger
as Small Hands

Luc Palun
as Amandine's Grocer

Fabienne Chaudat
as Woman in Coma

Dominique Bettenfeld
as Amélie's Neighbor

Jacques Viala
as Client Humiliating Friend

Fabien Béhar
as Humiliated Friend

Jonathan Joss
as Humiliated Friend's Son

Jean-Pierre Becker
as Homeless Man

Jean Darie
as Blind Man

Thierry Gibault
as Endive Client

François Bercovici
as Endive Client's Friend

Franck Monier
as Young Dominique

Guillaume Viry
as SDF

Valérie Zarrouk
as Dominique's Wife

Marie-Laure Descoureaux
as Concierge of the Dead

Sophie Tellier
as Aunt Josette

Gérald Weingand
as Teacher

François Viaur
as Bistro Owner

Paule Daré
as Bistro Employee

Marc Amyot
as Unknown at Photo Booth

Myriam Labbé
as Tobacco Store Costumer

Jean Rupert
as Operated on the Nasal Septa

Frankie Pain
as Newspaper Seller

Julianna Kovacs
as Grocery Customer

Philippe Paimblanc
as Train Controller

Mady Malroux
as Twin #1

Monette Malroux
as Twin #2

Robert Gendreu
as Café Customer

Valériane de Villeneuve
as Laughing Woman

Isis Peyrade
as Samantha

Raymonde Heudeline
as Ghost Train Cashier

Christiane Bopp
as Woman Near Merry-Go-Round

Thierry Arfeuillères
as Man Statue

Jerry Lucas
as Little Boy of Sacré-Coeur

Patrick Paroux
as Street Blower

François Aubineau
as Concierge's Postman

Philippe Beautier
as Poulain's Postman

Karine Asure
as Pretty Girl

Régis Iacono
as Félix L'Herbier

Franck-Olivier Bonnet
as Palace Video (voice)

Alain Floret
as Concierge's Husband (voice)

Jean-Pol Brissart
as Jacques Grosjean (voice)

Frédéric Mitterrand
as Frédéric Mitterrand (voice)

Laurent Delpit
as Montmartre Man (uncredited)

Manoush
as Nymphomaniac (uncredited)

Jacques Thébault
as (voice) (uncredited)

Dean Baykan
as (uncredited)

Clément Chebli
as (uncredited)

Eloïse Labro
as (uncredited)