Owen Wilson
as Reggie (voice)

Woody Harrelson
as Jake (voice)

Amy Poehler
as Jenny (voice)

George Takei
as S.T.E.V.E. (voice)

Colm Meaney
as Myles Standish (voice)

Keith David
as Chief Broadbeak (Voice)

Dan Fogler
as Governor William Bradford (voice)

Jimmy Hayward
as Ranger / Leatherbeak / President / Hazmats (voice)

Jeff Biancalana
as General Sagan / Hazmats (voice)

Danny Carey
as Danny (voice)

Carlos Ponce
as Narrator / Alejandro (voice)

Robert Beltran
as Chief Massasoit (voice)

Lesley Nicol
as Female Pilgrim (voice)

Kaitlyn Maher
as President's Daughter (voice)

Carlos Alazraqui
as Amos (voice)

Josh Lawson
as Gus (Voice)

Jason Finazzo
as Chrononaut One (voice)

Scott Mosier
as Pizza Dude (voice)

Lauren Bowles
as Jake's Mother (voice)

Dwight Howard
as Cold Turkey (Voice)

Vincente DiSanti
as (voice)

Jeff Fierson
as (voice)

David S. Lee
as (voice)

Rik Michul
as (voice)

Alina Phelan
as (voice)

William Morgan Sheppard
as (voice)