Jamie Foxx
as Ray Charles

Kerry Washington
as Della Bea Robinson

Regina King
as Margie Hendricks

Harry Lennix
as Joe Adams

Clifton Powell
as Jeff Brown

Bokeem Woodbine
as Fathead Newman

Sharon Warren
as Aretha Robinson

C.J. Sanders
as Young Ray Robinson

Curtis Armstrong
as Ahmet Ertegun

Richard Schiff
as Jerry Wexler

Larenz Tate
as Quincy Jones

Terrence Howard
as Gossie McGee

David Krumholtz
as Milt Shaw

Wendell Pierce
as Wilbur Brassfield

Aunjanue Ellis-Taylor
as Mary Ann Fisher

Chris Thomas King
as Lowell Fulson

Thomas Jefferson Byrd
as Jimmy

Rick Gomez
as Tom Dowd

Denise Dowse
as Marlene

Warwick Davis
as Oberon

Patrick Bauchau
as Dr. Hacker

Robert Wisdom
as Jack Lauderdale

Kurt Fuller
as Sam Clark

Jedda Jones
as Mercedes

Gary Grubbs
as Billy Ray

Carol Sutton
as Eula

Paula Jai Parker
as Ruth Brown

Eric O'Neal Jr.
as Ray Charles Jr. - 5-6 Yrs.

Tequan Richmond
as Ray Charles Jr. - 9-10 Yrs.

Ayanna Tatum
as Woman in Sandpiper Lounge (uncredited)