Dan Aykroyd
as Louis Winthorpe III

Eddie Murphy
as Billy Ray Valentine

Ralph Bellamy
as Randolph Duke

Don Ameche
as Mortimer Duke

Denholm Elliott
as Coleman

Kristin Holby
as Penelope Witherspoon

Paul Gleason
as Clarence Beeks

Jamie Lee Curtis
as Ophelia

Alfred Drake
as President of Exchange

Bo Diddley
as Pawnbroker

Frank Oz
as Corrupt Cop

Jim Belushi
as Harvey

Al Franken
as Baggage Handler #1

Tom Davis
as Baggage Handler #2

Maurice Woods
as Duke & Duke Employee

Richard D. Fisher, Jr.
as Duke & Duke Employee

Jim Gallagher
as Duke & Duke Employee

Anthony DiSabatino
as Duke & Duke Employee

Bonnie Behrend
as Duke & Duke Employee

Sunnie Merrill
as Duke & Duke Employee

James Newell
as Duke & Duke Employee

Mary St. John
as Duke & Duke Employee

Bonnie Tremena
as Duke & Duke Employee

David Schwartz
as Duke & Duke Employee

Tom Degidon
as Duke Domestic

William Magerman
as Duke Domestic

Alan Dellay
as Duke Domestic

Florence Anglin
as Duke Domestic

Ray D'Amore
as Duke Domestic

Bobra Suiter
as Duke Domestic

Herb Peterson
as Duke Domestic

Sue Dugan
as Duke Domestic

Walt Gorney
as Duke Domestic

B. Constance Barry
as Duke Domestic

P. Jay Sidney
as Heritage Club Doorman

Avon Long
as Ezra

Tom Mardirosian
as Officer Pantuzzi

Charles Brown
as Officer Reynolds

Robert Curtis Brown
as Todd

Nicholas Guest
as Harry

John Bedford Lloyd
as Andrew

Tony Sherer
as Philip

Robert Earl Jones
as Attendant

Robert E. Lee
as Cop #1

Peter Hock
as Cop #2

Clint Smith
as Doo Rag Lenny

Ron Taylor
as Big Black Guy

James D. Turner
as Even Bigger Black Guy

Giancarlo Esposito
as Cellmate #2

Steve Hofvendahl
as Cellmate #3

James Eckhouse
as Guard

Gwyllum Evans
as President of Heritage Club

Eddie Jones
as Cop #3

John McCurry
as Cop #4

Michelle Mais
as Hooker #1

Barra Khan
as Hooker #2

Bill Cobbs
as Bartender

Joshua Daniel
as Party Goer

Jacques Sandulescu
as Creepy Man

W.B. Brydon
as Bank Manager

Margaret H. Flynn
as Duke & Duke Receptionist

Kelly Curtis
as Muffy

Tracey K. Shaffer
as Constance

Susan Fallender
as Bunny

Lucianne Buchanan
as President's Mistress

Paul Garcia
as Jr. Executive #1

Jed Gillin
as Jr. Executive #2

Jimmy Raitt
as Ophelia's Client

Kate Taylor
as Duke's Secretary

Philip Bosco
as Doctor

Bill Boggs
as Newscaster

Deborah Reagan
as Harvey's Girlfriend

Don McLeod
as Gorilla

Stephen Stucker
as Stationmaster

Richard Hunt
as Wilson

Paul Austin
as Trader #1

John Randolph Jones
as Trader #2

Jack Davidson
as Trader #3

Bernie McInerney
as Trader #4

Maurice Copeland
as Secretary of Agriculture

Ralph Clanton
as Official #1

Bryan Clark
as Official #2

Gary Klar
as Longshoreman

Afemo Omilami
as Longshoreman

Shelly Chee Chee Hall
as Monica

Donna Palmer
as Gladys

Barry Dennen
as Demitri

Murray Bandel
as Man at Police Station (uncredited)

Benjean
as Stray Dog (uncredited)

John Black
as Man Sitting on Couch at Party (uncredited)

John Landis
as Man with Briefcase (uncredited)

Shirley Levine
as Bag Lady (uncredited)

Charles Pendelton
as Cop (uncredited)

Yvonna Russell
as Girl in Park (uncredited)

Jan Saint
as Man in Police Station (uncredited)

Arleen Sorkin
as Woman at Party (uncredited)

Ronald Sylvers
as Rolls Royce Driver (uncredited)

Marlene Willoughby
as Woman Passed Out on Couch (uncredited)