Ben Stiller
as Larry Daley

Carla Gugino
as Rebecca

Dick Van Dyke
as Cecil

Mickey Rooney
as Gus

Bill Cobbs
as Reginald

Jake Cherry
as Nick Daley

Ricky Gervais
as Dr. McPhee

Robin Williams
as Theodore Roosevelt

Kim Raver
as Erica Daley

Patrick Gallagher
as Attila the Hun

Rami Malek
as Ahkmenrah

Pierfrancesco Favino
as Christopher Columbus

Charlie Murphy
as Taxi Driver

Steve Coogan
as Octavius

Mizuo Peck
as Sacajawea

Kerry van der Griend
as Neanderthal #1

Dan Rizzuto
as Neanderthal #2

Matthew Harrison
as Neanderthal #3

Jody Racicot
as Neanderthal #4

Paul Rudd
as Don

Anne Meara
as Debbie

Martin Christopher
as Lewis

Martin Sims
as Clark

Randy Lee
as Hun #1

Darryl Quon
as Hun #2

Gerald Wong
as Hun #3

Paul Chih-Ping Cheng
as Hun #4

Teagle F. Bougere
as Teacher (Mike)

Pat Kiernan
as TV News Anchor

Nico McEown
as Friend #1

Meshach Peters
as Friend #2

Matthew Walker
as Politician

Jason McKinnon
as Irish Worker

Jono Lee
as Chinese Rail Worker

Jason Vaisvila
as Viking

Cade Wagar
as Viking

Cory Martin
as Chinese Terra Cota Soldier

Brad Garrett
as Easter Island Head (voice)

Crystal the Monkey
as Dexter

Che Landon
as Pretty Tourist Girl (uncredited)

Phil Proctor
as Moose (uncredited)

Gary Sievers
as Viking Warrior (uncredited)

Owen Wilson
as Jedediah Smith (uncredited)