Matthew McConaughey
as Ron Woodroof

Jennifer Garner
as Eve

Jared Leto
as Rayon

Denis O'Hare
as Dr. Sevard

Steve Zahn
as Tucker

Michael O'Neill
as Richard Barkley

Dallas Roberts
as David Wayne

Griffin Dunne
as Dr. Vass

Kevin Rankin
as T.J.

Donna DuPlantier
as Nurse Frazin

Deneen Tyler
as Denise

J.D. Evermore
as Clint

Ian Casselberry
as Hispanic Orderly

Noelle Wilcox
as Kelly

Bradford Cox
as Sunny

Rick Espaillat
as Michael

Lawrence Turner
as Foreman

Lucius Falick
as Freddie

James DuMont
as Rayon's Father

Jane McNeill
as Francine Suskind

Don Brady
as Tucker's Father

Matthew Thompson
as Effeminate Man

Tony Bentley
as Judge

Sean Boyd
as Border Agent

Rachel Wulff
as News Anchor

Neeona Neal
as Stripper

Scott Takeda
as Mr. Yamata

Jonathan Tabler
as Rick Ferris

Joji Yoshida
as Dr. Hiroshi

Carl Palmer
as FDA Customs Agent

Martin Covert
as Ian

Douglas M. Griffin
as Rog

David Lichtenstein
as Cop

Craig Borten
as Quicksilver Cowboy

Henry Frost
as Gay Cowboy

Arthur Smith
as Rodeo Announcer

Adam Dunn
as Neddie Jay (uncredited)

Juliet Reeves London
as Rodeo Girl (uncredited)

Jeanine Hill
as Rodeo Girl (uncredited)

Sarah Eilts
as Ron's Hooker (uncredited)

Lily Virginia Filson
as Dancer (uncredited)

Steffie Grote
as The Girl With The Snake Tattoo (uncredited)