Michelle Pfeiffer
as Rosie

Paul Rudd
as Adam Perl

Saoirse Ronan
as Izzie Mensforth

Tracey Ullman
as Mother Nature

Stacey Dash
as Brianna Minx

Fred Willard
as Marty

Jon Lovitz
as Nathan Mensforth

Sarah Alexander
as Jeannie

Yasmin Paige
as Melanie

Graham Norton
as Taylor

David Mitchell
as David - Writer

O-T Fagbenle
as Sean Jamal Knight

Rory Copus
as Dylan

Steve Pemberton
as Censor

Henry Winkler
as Self

Twink Caplan
as Sissy

Ashley Lloyd
as Zak

Wallace Shawn
as Izzie's Teacher

Mackenzie Crook
as Producer

Peter Polycarpou
as 2nd Producer

Olivia Colman
as Hairdresser

Archie Panjabi
as Casting Girl

Ed Byrne
as Delivery Boy

Chike Chan
as Allergy Actor

Troy Gentile
as Fighting Boy

Sally Kellerman
as Self

Phil Cornwell
as Cameraman

Iddo Goldberg
as Director

Noah Lee Margetts
as Monty

Jonathan Ryland
as Prop Guy

Simon Kunz
as Intruder

Victoria Chalaya
as Nathan's Wife

Doña Croll
as Marty's Secretary

Cassandra Bell
as Pretty Waitress

Sam Fusaro
as Bouncer

Jennifer Sims
as Parent 2

Joe Montana
as Very Large Guy

Melanie Martin
as Sean's Wife (uncredited)

Kya Garwood
as You go girl crew (uncredited)

Erin Gavin
as Dancer (uncredited)

David Cassidy
as Self (archive footage) (uncredited)

Richard Nixon
as Self (archive footage) (uncredited)

Benito Mussolini
as Self (archive footage) (uncredited)

Rene Costa
as Diner (uncredited)