Will Ferrell
as Harold Crick

Maggie Gyllenhaal
as Ana Pascal

Dustin Hoffman
as Professor Jules Hilbert

Emma Thompson
as Karen Eiffel

Queen Latifah
as Penny Escher

Tony Hale
as Dave

William Dick
as IRS Co-Worker #1

Guy Massey
as IRS Co-Worker #2

Martha Espinoza
as IRS Co-Worker #3

T.J. Jagodowski
as IRS Co-Worker #4

Peter Grosz
as IRS Co-Worker #5

Tonray Ho
as IRS Co-Worker #6

Herb Lichtenstein
as IRS Co-Worker #7

Stacey Elaine Jackson
as IRS Co-Worker #8

Ricky Adams
as Young Boy

Christian Stolte
as Young Boy's Father

Denise Hughes
as Kronecker Bus Driver

Peggy Roeder
as Polish Woman

Danny Rhodes
as Bakery Employee #1

Linara Washington
as Bakery Employee #2

Helen Young
as Bakery Customer #1

David Pompeii
as Bakery Customer #2

David Wiegers
as Bakery Customer #3

Jarrett Sleeper
as Bakery Customer #4

Larry Neumann Jr.
as Homeless Man

John Mohrlein
as Man with Hose

Tom Hulce
as Dr. Cayly

Bruce Jarchow
as Commuter

Linda Hunt
as Dr. Mittag-Leffler

Kristin Chenoweth
as Book Channel Host

Bradley Mott
as Large Man on Bus

John M. Watson Sr.
as TV Author

Karen Lloyd
as Customer with Tan

Keith Kupferer
as Demolition Foreman

Danny McCarthy
as Demolition Crew #1

Tab Baker
as Demolition Crew #2

Mark Buettner
as Claw Operator

Christian Young
as ER Doctor #1

Ray Kurut
as ER Doctor #2

Michael Cook
as ER Doctor #3

Arraon Skippa Hixson
as Young Man Patient

Bryan Kelly
as ER Orderly

Whitney Sneed
as ER Nurse #1

Celeste Pechous
as ER Nurse #2

Cheryl Lynn Bruce
as Head ER Nurse

Chet Dubowski
as Man in Tweed

Ora Jones
as Banneker Press Receptionist

Jordan Keller
as Grocer

Jordan Teplitz
as Old Man on Phone

Ricardo Gutierrez
as Bus Company Manager

James Mazza
as Irritated Man on Bus

Oscar Roxas
as Another Man on Bus

Nadirah Bost
as Accident Witness

Sandra Marquez
as Accident Witness

Lacy Katherine Campbell
as Accident Witness

Will Clinger
as Accident Witness

Al Samuels
as Accident Witness

Frank Caeti
as Accident Witness

Andrew Rothenberg
as Doctor Mercator

Rengin Altay
as Nurse

Lucinda Kemp
as Bus Operator #1

Donna Watkins
as Bus Operator #2

Julia Heron
as Animal Footage Voice Over (voice)

Lora Cain
as Animal Footage Voice Over (voice)

Bob Papenbrook
as Animal Footage Voice Over (voice)

Mike McColl
as Animal Footage Voice Over (voice)

Nathan Adloff
as Bakery Patron (uncredited)

Sia A. Moody
as Nurse #3 (uncredited)

Eli Goodman
as Augustus Chatman (uncredited)

Edy Cullen
as Business Women (uncredited)

Tim Krueger
as Business Man (uncredited)