John Cusack
as Nick Falzone

Billy Bob Thornton
as Russell Bell

Cate Blanchett
as Connie Falzone

Angelina Jolie
as Mary Bell

Gene Dinovi
as Enzo Sorrento

Vicki Lewis
as Tina Leary

Kurt Fuller
as Ed Clabes

Jake Weber
as Barry Plotkin

Matt Ross
as Ron Hewitt

Mike O'Malley
as Pete

John Carroll Lynch
as Doctor Freeze

Catherine Lloyd Burns
as Tanya Hewitt

Sarah Knowlton
as Beverly

Molly Price
as Crystal Plotkin

Kiersten Warren
as Karen

Amanda Delaney
as Bodybuilder

Ramona Milano
as TV Reporter

Jenny Parsons
as Flight Attendant

Robyn Stevan
as Sara

Martin Roach
as Pilot (voice)