Chyler Leigh
as Janey Briggs

Chris Evans
as Jake Wyler

Jaime Pressly
as Priscilla

Eric Christian Olsen
as Austin

Mia Kirshner
as Catherine Wyler

Lacey Chabert
as Amanda Becker

Samaire Armstrong
as Kara Fratelli

Cerina Vincent
as Areola

Mr. T
as The Wise Janitor

Molly Ringwald
as Flight Attendant

Heather Brown
as Dainty Girl

Nectar Rose
as Sara Fratelli

Michael Ensign
as Father O'Flannagan

Kyle Cease
as Slow Clapper

Eric Jungmann
as Ricky Lipman

Desi Lydic
as Cutie

Deon Richmond
as Malik

Ron Lester
as Reggie Ray

Cody McMains
as Mitch Briggs

Sam Huntington
as Ox

JoAnna García Swisher
as Sandy Sue

Samm Levine
as Bruce

Beverly Polcyn
as Sadie Agatha Johnson

Ed Lauter
as The Coach

Paul Gleason
as Richard Vernon

Randy Quaid
as Mr. Briggs

Riley Smith
as Les

Nathan West
as Actor

Michelle Holgate
as Actress

Jeanette Miller
as Grandma Briggs

Benjamin Waldow
as Kid

Josh Radnor
as Tour Guide

Alec Murdock
as Man in Line

Ross Mulholland
as Cheerleader in Front of School

Dean Sheremet
as Cheerleader in Front of School

Becca Sweitzer
as Cheerleader in Front of School

Hayley Zelniker
as Cheerleader in Front of School

Lukas Behnken
as White Guy

Josh Jacobson
as White Guy

Amber Goetz
as White Girl

Joy Bisco
as Ashley

Morisa Taylor Kaplan
as Heather

George Wyner
as Mr. Cornish

Ned Brower
as Dude

Peter Simon
as Dude

Joy Gohring
as Albino Folk Singer

Tracy Kay
as Hottie

Jessica Asher
as Naked Girl in Locker Room

Sean Smith
as Mr. Keller

Ean Mering
as Marty

Lyman Ward
as Mr. Wyler

Julie Welch
as Mrs. Wyler

Daniel Bess
as Panicked Student

James Read
as Preston's Father

Rob Benedict
as Preston Wasserstein

Banks McClintock
as Keg Guy

Jay Johnston
as Roadie

Jesse Capelli
as Naked Girl at Party

Daniel Spink
as Curious Guy

Osgood Perkins
as Uninterested Guy

Jim Wise
as Football Announcer

Kimi Bateman
as Cheerleader on Football Field

Staci B. Flood
as Cheerleader on Football Field

Sarah Christine Smith
as Cheerleader on Football Field

China Shavers
as North Compton Cheerleader

H. Jon Benjamin
as Trainer

Paul Goebel
as Fat Short Order Cook

Marissa Fedele
as Dancer

Samuel Givens
as Dancer

Kimberly Lyon
as Dancer

Zachary Woodlee
as Dancer

Cynthena Sanders
as Woman in Line

Will Gill Jr.
as Security Guard

Nick Zephyrin
as Little Boy

Heidi Androl
as Molly

Ian Aronson
as Student

Sam Ayers
as Paramedic

Nick Bakay
as Diner Cook

Candice T. Cain
as Pom Pom Girl #3

Maylen Calienes
as Locker Student

Marcus Edward
as Teen with Drink at Party

Arturo Elizondo
as DJ Arte

David M. Francis
as Student

Melissa Joan Hart
as Slow Clapper's Instructor

Kelly S. King
as Art Student

Jarrett Lennon
as Partygoer

Tracey McCall
as Locker Room Girl

Jennifer Schlueter
as Student

Gena Shaw
as Party Girl

Tessa
as Slutty Girl-New Student

Sean Patrick Thomas
as Black Guy at Party

Cassie Townsend
as Student

Jeremiah Vaughn
as Marty's Buddy

Susan Anne Wall
as Flight Attendant

Scott Hislop
as Footloose Guy (uncredited)

Jackie Harris Greenberg
as Preston's Mother