Matthew McConaughey
as Mud

Reese Witherspoon
as Juniper

Tye Sheridan
as Ellis

Jacob Lofland
as Neckbone

Sam Shepard
as Tom

Ray McKinnon
as Senior

Sarah Paulson
as Mary Lee

Michael Shannon
as Galen

Joe Don Baker
as King

Paul Sparks
as Carver

Bonnie Sturdivant
as May Pearl

Stuart Greer
as Miller

John Ward Jr.
as Galen's Helper

Kristy Barrington
as Princess

Johnny Cheek
as Kyle

Kenneth Hill
as Nelson

Michael Abbott Jr.
as James

Earnest McCoy
as Man at Budget Inn

Allie Wade
as May Pearl's Friend

Douglas Ligon
as Motel Clerk

Matt Newcomb
as Male Nurse

Mary Alice Jones
as Female Nurse

Tate Smalley
as Older Kid at Food King

Jimmy Dinwiddie
as Bartender

Ryan Jacks
as Trooper at Roadblock

Richard Ledbetter
as Man on Street (uncredited)