Michael J. Fox
as Stuart Little (voice)

Chazz Palminteri
as Smokey (voice)

Nathan Lane
as Snowbell (voice)

Geena Davis
as Mrs. Little

Hugh Laurie
as Mr. Little

Jonathan Lipnicki
as George Little

David Alan Grier
as Red (voice)

Steve Zahn
as Monty (voice)

Jim Doughan
as Lucky / Officer Allen (voice)

Bruno Kirby
as Mr. Stout (voice)

Jennifer Tilly
as Mrs. Stout (voice)

Stan Freberg
as Race Announcer (voice)

Jeffrey Jones
as Uncle Crenshaw

Connie Ray
as Aunt Tina

Allyce Beasley
as Aunt Beatrice

Brian Doyle-Murray
as Cousin Edgar

Estelle Getty
as Grandma Estelle

Harold Gould
as Grandpa Spencer

Patrick Thomas O'Brien
as Uncle Stretch

Julia Sweeney
as Mrs. Keeper

Dabney Coleman
as Dr. Beechwood

Miles Marsico
as Anton

Jon Polito
as Officer Sherman

Joe Bays
as Race Starter

Taylor Negron
as Salesman

Kimmy Robertson
as Race Spectator

Tannis Benedict
as Hot Dog Vendor

Chuck Blechen
as Skipper

Westleigh M. Styer
as Skipper

Larry Goodhue
as Boat Registrar

Joshua Paule
as New Yorker (uncredited)